The Wagon Wheel Motel, Café and Station in Cuba, Missouri, is a 19-room independently owned historic U.S. Route 66 restored motel which has been serving travelers since 1938. The site opened as a café in 1936; the motel has remained in continuous operation since 1938. The motel rooms were fully restored in 2010, adding modern amenities such as HDTV and wireless Internet.
A filling station which once also occupied the original 1936 property is no longer in active use; the original Wagon Wheel Café restaurant is now a retail store filled with jewelry, purses, decor, Route 66 books, T-shirts and a few original Wagon Wheel antiques. The property has been listed on the National Register of Historic Places since 2003.